"What we discovered," Blumberg said, is that tributyltin disrupted genetic interactions that regulate fat-cell activity in animals. "Exposure to tributyltin is increasing the number of fat cells, so the individual will get fatter faster as these cells produce more of the hormones that say 'feed me,'" Blumberg said. The exposed animals, he added, remain predisposed to obesity for life.
Others suspect the same thing happens with Bisphenol A. Frederick vom Saal of the University of Missouri's research indicates that developmental exposure to low doses of bisphenol A activates genetic mechanisms that promote fat-cell activity. "These in-utero effects are lifetime effects, and they occur at phenomenally small levels" of exposure.
We note that Nalgene continues to stand behind its bottles, and that others challenge Vom Saal's research, but plan to follow Warren's advice and buy aSigg. ::Washington Post see also how none of this is new at ::Our Stolen Future